Advanced features

The myNEO ImmunoEngine neoantigen prediction platform incorporates years of development ensuring confident identification of as many antigens as possible. The variety of filters/ranking mechanisms based on biological processes retain the neoantigen targets providing the most clinical benefit in terms of response strength, duration (memory induction), breadth, and overall survival.

The advanced features are divided amongst three modules, as per their purpose:

  • Tumour-specific variant: to identify all the tumour-specific alterations with high confidence based on the sequencing data of the tumour
  • Tumour-specific surface peptide: to predict which of the identified alterations will lead to changes in the presented antigen repertoire on the surface of the tumour cells.
  • Immunogenicity response: to evaluate the immunogenic impact of a therapy against the selected peptides

Tumour-specific variant

SNVs
SNVs
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Indels
Indels
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Gene fusions
Gene fusions
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mRNA splice variants
mRNA splice variants
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Retrotransposition
Retrotransposition
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ncRNA mutations
ncRNA mutations
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Mutational events
Mutational events
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Presentation alterations
Presentation alterations
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RNA editing
RNA editing
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Post-transl. modif.
Post-transl. modif.
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CNVs
CNVs
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Filtering

Transcription
Transcription
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High AF
High AF
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Specificity
Specificity
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High impact
High impact
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DB presence
DB presence
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Somatic mutation
Somatic mutation
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Mutagen specificity
Mutagen specificity
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High clonality
High clonality
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Tumour-specific surface peptide

Translational efficiency
Translational efficiency
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TAT protein
TAT protein
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Proteasomal degradation
Proteasomal degradation
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Peptide transport
Peptide transport
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TAP binding
TAP binding
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MHC I/II affinity
MHC I/II affinity
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pMHC stability
pMHC stability
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Neural network trained on ms

neoMS - NN trained on mass spec data
neoMS - NN trained on mass spec data
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Immunogenicity response

Peptide-specific

Mutant <> Normal
Mutant <> Normal
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Microbiome mimicry
Microbiome mimicry
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Virus-associated
Virus-associated
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T-cell interaction
T-cell interaction
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Patient-specific

Pooling T-cell reads
Pooling T-cell reads
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Immune contexture
Immune contexture
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Transcriptional profile
Transcriptional profile
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Clinical patient values
Clinical patient values
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Construct-specific

Epiconstruct selection
Epiconstruct selection
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Codon optimisation
Codon optimisation
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Junctional epitope identification
Junctional epitope identification
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