Scientific papers - myNEO personalised platform

Trends in Cancer Review: Neoantigen-directed therapeutics in the clinic - where are we?

In the past decade, immune checkpoint inhibitors (ICIs) and chimeric antigen receptor (CAR) T cell therapy have brought immunotherapy to the forefron…

Cancer Cell Review: Challenges in neoantigen-directed therapeutics

A fundamental prerequisite for the efficacy of cancer immunotherapy is the presence of functional, antigenspecific T cells within the tumor. Neoantig…

Whitepaper: Liquid biopsies in personalised medicine - Future and pitfalls

Liquid biopsies in personalised medicine: future and pitfalls Historically, the analysis of tumour tissue has been the primary mean through which …

Whitepaper: There is more to the genome - Increasing the range of actionable high-confidence neoantigen discovery by whole genome sequencing

Next-generation sequencing has become indispensable in current clinical diagnostics settings. In cancer settings in particular, sequencing enables th…

Whitepaper: Optimal neoantigen prediction and selection - Where’s the sweet spot?

To improve upon the current efficacy rate of cancer therapeutics, a careful approach should be taken to identify epitopes (neoantigens) capable of gu…

Drug Target Review: Immunosurveillance and the importance of CD4 T-cells in cancer

**Featured in Drug Target Review** The immune-oncology field has emerged based on a concept called cancer immunoediting which describes the dual r…

Whitepaper: How the Gut Microbiome affects Cancer Immunotherapy

It has been widely established that the gut microbiota influences numerous and diverse physiological functions, hence has a prevalent role in human h…

Whitepaper: Beyond SNVs and indels for neoantigen prediction in cold tumours

Cancer immunotherapy, in particular checkpoint inhibitor (CPI) therapy, has drastically changed the oncology field which has evoked a complete shift …

Whitepaper: The promise of personalised cancer vaccination

This whitepaper describes the great promise of personalised cancer vaccination alongside its challenges. The main advantages of cancer vaccination…

Whitepaper: Is immunotherapy the holy grail in the fight against cancer?

This whitepaper describes the milestones and challenges of immuno-oncology thereby giving a broad overview of what is necessary to push immunotherapy…